Research Studies

Study Title: Determination of Lung Cancer Drug Susceptibility

Purpose: The purpose of this study is to determine whether individualized chemotherapy protocols can be identified among lung cancer patients by growing living lung cancer cells from lung biopsies and then perform drug toxicity studies with a panel of chemotherapeutic agents.

Background: The majority of lung cancers have metastasized by the time cancer has been diagnosed. Lung cancer is categorized into either small cell or non-small cell cancer. The majority of lung cancers are of the non-small cell type. Most non-small cell lung cancer are resistant to chemotherapy, and chemotherapy has a modest impact on achieving remission or improving cancer survival. The purpose of this study is isolate and grow lung cancer cell lines from lung biopsies and perform drug susceptibility to determine whether there are potential individualized lung cancer therapies.

Location: Pulmonary Associates of Iowa City.

Sponsors: John Paul II Stem Cell Research Institute and Cellular Engineering Technologies, Inc.

Eligibility: Potential new cancer patients or established lung cancer patients who are candidates for either lung cancer surgery or candidates for diagnostic bronchoscopy.

Study Title: Determining cardiovascular risk by measuring cardiovascular stem cells

Purpose: The purpose of this study is to measure cardiovascular stem cells in patients at risk of cardiovascular disease and determine if deficiences in cardiovascular stem cells are associated with cardiovascular malfunction. The study will recruit patients at risk of cardiovascular disease but without cardiovascular disease, patients with established cardiovascular disease and normal controls.

Background: Framingham risk factors such as smoking, hypertension, diabetes, hyperlipidemia and positive family history represent cardiovascular risk factors that place patients at higher risk of developing cardiovascular disease. However, recent studies have demonstrated that deficiencies in circulating cardiovascular stem cells are better predictors of cardiovascular malfunction and predict worse cardiovascular outcomes than these established Framingham risk factors. The purpose of this study is to determine the potential impact of deficiencies in cardiovascular stem cells called endothelial progenitor cells in developing cardiovascular impairment.

Location: Pulmonary Associates of Iowa City.

Sponsors: John Paul II Stem Cell Research Institute and Cellular Engineering Technologies, Inc.

Eligibility: Normal controls, patients with cariovascular risk factors (hypertension, smokers, diabetes, hyperlipidemia) without cardiovascular disease and patients with established cardiovascular disease. We are recruiting patients over the age of 45.

A government registry exists for federal and privately supported clinical trials for several clinical disorders. ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals. For more information, please check out the following link: http://clinicaltrials.gov/ct2/home

CRISP (Computer Retrieval of Information on Scientific Projects) is a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions. The database, maintained by the Office of Extramural Research at the National Institutes of Health, includes projects funded by the National Institutes of Health (NIH), Substance Abuse and Mental Health Services (SAMHSA), Health Resources and Services Administration (HRSA), Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDCP), Agency for Health Care Research and Quality (AHRQ), and Office of Assistant Secretary of Health (OASH). Users, including the public, can use the CRISP interface to search for scientific concepts, emerging trends and techniques, or identify specific projects and/or investigators. You will be able to access additional general information about the CRISP database, as well as obtain answers to questions frequently asked about CRISP. In addition, this home page serves as the gateway to interactive searching of Award Information. From here, you may select from the following list to acquire further information about CRISP: http://crisp.cit.nih.gov

PubMed is a service of the U.S. National Library of Medicine that includes over 17 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.


Pulmonary Associates of Iowa City· 540 E. Jefferson St, Suite 202 · Iowa City, IA 52245 · office (319) 887-2873; (fax) 319-887-2870